Synaptic functions in rat sympathetic neurons in microcultures. II. Adrenergic/cholinergic dual status and plasticity
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Synaptic functions in rat sympathetic neurons in microcultures. II. Adrenergic/cholinergic dual status and plasticity.
This is the second in a series of papers that describes the use of a sensitive microculture procedure to investigate the transmitter status of sympathetic neurons. Cultured immature principal neurons, dissociated from the superior cervical ganglia of newborn rats, are known to be plastic with respect to transmitter status; under certain culture conditions, populations of neurons that display (a...
متن کاملSynaptic functions in rat sympathetic neurons in microcultures. I. Secretion of norepinephrine and acetylcholine.
This is the first of a series of four papers that describes the use of a sensitive "microculture" procedure for examining the neurotransmitter profile of a neuron by assaying the transmitter(s) it releases. Sympathetic principal neurons isolated from the superior cervical ganglia of neonatal or adult rats were grown for 10 d to several months on small islands of cardiac myocytes (island diamete...
متن کاملSynaptic functions in rat sympathetic neurons in microcultures. III. A Purinergic effect on cardiac myocytes.
In the first two of this series of papers, a sensitive microculture procedure was used to show that rat sympathetic neurons grown singly on small islands of heart cells release norepinephrine (NE) and/or acetylcholine (ACh). We report here the release of a third transmitter in response to stimulation of these neurons. This agent was recognized by its effect on the cocultured cardiac myocytes: a...
متن کاملSynaptic functions in rat sympathetic neurons in microcultures. IV. Nonadrenergic excitation of cardiac myocytes and the variety of multiple-transmitter states.
In the first 3 papers of this series (Furshpan et al., 1986a, b; Potter et al., 1986), a sensitive microculture procedure was used to show that sympathetic principal neurons, dissociated from newborn or adult superior cervical ganglia and grown singly on cardiac myocytes, display adrenergic, cholinergic, and purinergic functions, sometimes in isolation but more often in combination. In this pap...
متن کاملPostnatal rat sympathetic neurons in culture. II. Synaptic transmission by postnatal neurons.
1. It was shown in the preceding paper that postnatally derived rat superior cervical ganglion neurons (SCGN) will grow in dissociated cell culture and form functional synaptic connections with each other. In this report, synaptic transmission by the postnatal SCGN is detailed. 2. Synaptic interactions between SCGN were blocked by the nicotinic cholinergic antagonist hexamathonium (C-6), indica...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1986
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.06-04-01080.1986